Theranostic particle systems at Fraunhofer ISC

Particle systems for in vitro diagnostics

Nanoparticles are promising tools for a wide range of in vitro diagnostic methods. At the Fraunhofer TLC-RT, there is a broad portfolio of (nano)particle systems available for a wide variety of questions. Within our portfolio, we focus on optically based methods.

Particle systems for medical imaging

In recent years, diagnostic imaging has become an important approach in the field of medicine. Besides the classical technology of X-ray examination, contrast-rich methods like computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and ultrasonic techniques are often applied in the soft tissue area. The combination of the different diagnostic methods results in a more detailed and accurate diagnosis.

Contrast agents are used to improve the representation of structures and functions of the body by increasing sensitivity and reducing ambiguity in imaging techniques routinely. Fraunhofer ISC develops multifunctional (nano-)particles which are verifiable by different detection techniques (photoluminescence, photoacoustics, MRI) and allow a non-destructive imaging of biological processes.

Particle systems for therapy

Due to their size and their adjustable properties, there is an increased application of nanoparticles in therapy. On the one hand, they can be applied as carrier for medical active substances and, on the other hand, be a therapeutic agent itself.

In their role as drug carrier they can encapsulate sensitive drugs. The particle matrix protects the active substances from outside impacts and enables the controlled drug release. Due to tailor-made structure and surface properties, the particles can be targeted to the respective location which enables a optimal dosage and reduces side effects.

Besides the (nano)particle development, we can also offer commissioned synthesis and functionalizion of inorganic and hybrid particle systems as well as process upscaling including complete synthesis monitoring and documentation.